Mitragyna Speciosa or Kratom, as it is widely known, is an herb that has the same properties as that found in opioids. This plant belongs to the coffee family and grows in various regions in Southeast Asia that include Malaysia, Thailand, Papua New Guinea, Indonesia and Myanmar. The leaves of Kratom are used for making tablets, powders, extracts, tinctures and capsules and they can come in handy for treating musculoskeletal pain, treating sleep disorders and for enhancing sexual desire, energy and cognition as well. In some parts of the world, the leaves of this plant are also used for treating cough, hypertension and diarrhea.
Kratom gained popularity worldwide because it could be used as a remedy for treating chronic pain and for countering opioid withdrawal symptoms too. It is a non-prescription medication so you can easy find it online. There are more than 40 alkaloids in this particular plant that serve as its active ingredients by having an impact on the monoaminergic and opioid receptors. The primary alkaloid is Mitragynine, which acts as an agonist at some opioid receptors, which are responsible for the serotonin, dopamine and other chemicals in the body. You will see an onset action within 10 to 30 minutes of taking Kratom.
As for the effects, they can last for anywhere between 2 and 6 hours because they can vary as per the strain you have consumed. The structure of Mitragynine is quite similar to that of yohimbine and voacangine and it acts as a painkiller when taken in higher doses. No psychedelic effects are induced as the Phase I and Phase II microsomal system metabolize it.
The 7-hydroxymitragynine is another important alkaloid that can be found in Kratom, but is only 2% of the total alkaloids found in the plant. Furthermore, this alkaloid acts as a selective full agonist on the opioid receptors and has a stronger impact on the mu opioid receptors as opposed to mitragynine. Due to its interaction with these receptors, the alkaloid is able to cause analgesia. There are also other alkaloids that serve as active ingredients in Kratom and they include mitraphylline, mitragynine pseudoindoxyl, rhynchophylline, ajmalicine and plenty more.
There are not just alkaloids that make up Kratom; it also has some terpenoid saponins, glycosides, flavonoids and different polyphenols. The combination of these active ingredients have provided Kratom with its unique properties that has earned the plant the status of alternative medicine. As it is natural, it is perfectly safe for people to use Kratom for dealing with a number of health issues. However, it is vital to remember that you need to be careful about the dosage. The effects produced by this herbal remedy can depend on the dose.
Small doses are excellent if you are looking for stimulant effects whereas large doses enable Kratom to work as a sedative. You can use all Kratom strains as they are quite safe to be used for medicinal purposes. It is recommended that you start with a small dose and up it gradually for getting the right results.